CBD_10 NAT and CBD_40 MAX

Advanced anti-blemish technology: regulating, soothing and protective action.

A multifunctional active that targets the main causes of acne and hair loss, offering an innovative, safe, and effective solution for skin and hair care.

Cannabidiol (CBD) is a non-psychoactive bioactive compound extracted from Cannabis sativa, widely recognized for its powerful antioxidant and anti-inflammatory properties. It helps reduce oxidative stress, modulate the inflammatory response, and promote skin regeneration, making it a reference ingredient in current cosmetic innovation.

Thanks to Optidel technology, its solubility, bioavailability, and stability are enhanced, boosting its effectiveness in cosmetic and hair care products.

This optimized CBD hydrates, soothes, repairs, and protects, offering visible and long-lasting benefits.

check_circleThe innovative Optidel technology maximizes CBD concentration, ensuring its stability and bioavailability to visibly improve hair health and enhance its effects on the skin.
check_circleThanks to its advanced structure, CBD_10 NAT and CBD_40 MAX are the easiest and most effective way to incorporate cannabidiol into all types of cosmetic and hair formulations, taking skin and hair care to the next level.

How does it work?

Sebum-regulating and anti-acne without side effects

Regulates sebaceous gland activity and reduces bacterial proliferation without irritation or dryness

Next-generation antioxidant

Neutralizes free radicals and protects against oxidative damage induced by UV, pollution, or stress

Natural anti-inflammatory

Reduces the synthesis of inflammatory cytokines (such as TNF-α, IL-6), helping to calm irritated, reactive, or red skin and scalp

Neurosensory soothing effect

Reduces skin sensitivity by modulating peripheral neuronal transmission

Restores skin homeostasis

Promotes the skin’s natural balance by regulating key cellular processes

Dysbiosis: microbiota imbalance causes acne and hair loss.

An imbalance in the microbiota, known as dysbiosis, can trigger inflammation and affect the health of the skin and scalp, potentially contributing to acne and hair loss.

Cellular consequences

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Local chronic inflammation

Cellular oxidative stress

Follicular hyperkeratinization

Seborrhea

Pruritus (itching)

Visible consequences

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Acne

Erythema

Post-acne marks

Flaking (dandruff)

Inflammation and irritation

Excess sebum

In some cases, alopecia

In-vitro Efficacy

Antioxidant effect: ROS activity test

CBD_40 MAX

Reduction of 65% (ROS)

CBD_10 NAT

Reduction of 47% (ROS)

Treatment with CBD_40 MAX at 0.1% (0.04% CBD) reduced ROS production by 65% in damaged cells.

With CBD_10 NAT at 0.1% (0.01% CBD), the observed reduction was 47%

See graph

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ROS production (percentage) in the HaCaT keratinocyte cell line obtained from the antioxidant assay after 4 hours of exposure to tBPH with the test ingredient at the indicated concentrations. The positive control, tBPH insult, represents cells with the oxidizing agent tBPH alone. Bars represent the mean of six technical replicates of one independent experiment. Error bars represent standard deviation. Statistical significance * p < 0.005.

Anti-inflammatory activity

CBD_40 MAX

Reduces inflammation by up to 45%

CBD_40 MAX shows powerful anti-inflammatory ability, significantly reducing IL-8 levels (>40%) and TNF-α (>30%). This positions it as an innovative and effective ingredient for calming, repairing, and protecting skin and scalp under intense inflammatory conditions.

Treatment with CBD_40 MAX at 0.1% [CBD: 0.04] showed a reduction in inflammation of over 40% in inflammatory response (IL-8 secretion)
And a 45% reduction in TNF-α secretion

See graph

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The anti-inflammatory efficacy of CBD_40 MAX was studied in a human immune system cell line (THP-1 monocytes) differentiated into macrophages. The insult was induced using LPS (lipopolysaccharides from E. Coli), and anti-inflammatory capacity was evaluated through analysis of inflammatory cytokines (IL-8) and pro-inflammatory cytokines (TNF-α). Statistical significance * p < 0.005.

CBD_10 NAT

Reduces inflammation by up to 38%

Potent soothing and protective action: less redness, less discomfort, visibly more balanced and resilient skin.

CBD_10 NAT reduces inflammation by up to 20% (IL-8) and lowers TNF-α levels by more than 38%, both key markers of damage and irritation.

Soothing and protective efficacy even at low concentrations

See graph

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The anti-inflammatory efficacy of CBD_10 NAT was studied in a human immune system cell line (THP-1 monocytes) differentiated into macrophages. The insult was induced using LPS (lipopolysaccharides from E. Coli), and anti-inflammatory capacity was evaluated through analysis of inflammatory cytokines (IL-8) and pro-inflammatory cytokines (TNF-α). Statistical significance * p < 0.005.

In-vivo Efficacy

Overall facial improvement evaluation

PROTOCOL

Volunteers: 20 volunteers ♀♂

Age: >20 years

Study duration: 28 days

Frequency: 1 ampoule/day on cleansed face

Results: comparison with day 0 (pre-treatment)

Application area: face

Tested sample: ampoule with 2.5% Optidel CBD_10 NAT solution

See graph

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Subjective facial efficacy (% satisfied volunteers)

Facial improvement after 14 and 28 days of application

Visioscan® VC 2 plus

Overall improvement in hair and scalp

PROTOCOL

Volunteers: 20 volunteers ♀♂

Age: >20 years

Study duration: 28 days

Frequency: 1 ampoule/night on the scalp. Wash in the morning

Results: comparison with day 0 (pre-treatment)

Application area: scalp

Tested sample: ampoule with 2.5% Optidel CBD_10 NAT solution

See graph

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Scalp improvement after 14 and 28 days of application

Application

O/W creams and lotions – Soothing treatments for sensitive or irritated skin – Products for acne-prone or seborrheic skin – Anti-hair loss shampoos and lotions – Scalp treatments for sensitivity or seborrhea – Anti-dandruff products

Recommended dosage: 1% - 5%

Formulation tips

Add to bulk during the final production phase, ensuring the temperature does not exceed 40°C.

Add to the mixture and stir until homogeneous.

Active content (% w/w)

Cannabidiol (CBD) 40% and 10%

INCI name

CBD_40 MAX: Propylene glycol, cannabidiol
CAS: 57-55-6; 13956-29-1

CBD_10 NAT: Propanediol, cannabidiol
CAS: 504-63-2 / 26264-14-2; 13956-29-1

Documentation

If you want to learn all the details about Optidel CBD_40 MAX and CBD_10 NAT, here you can download the documentation. You’ll find information about their properties, how to use them, and the best recommendations to get the most out of them.

downloadCBD40Max-Ficha-Técnica.pdf downloadCBD40Max-Technical-Sheet.pdf downloadCBD40Max-Ficha-de-seguridad.pdf downloadCBD40Max-Safety-sheet.pdf downloadCBD10Nat-Ficha-Técnica.pdf downloadCBD10Nat-Technical-Sheet.pdf downloadCBD10Nat-Ficha-de-seguridad.pdf downloadCBD10Nat-Safety-sheet.pdf downloadPresentación-Ingredientes.pdf downloadIngredients-Presentation.pdf

Other Ingredients in Our Portfolio

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Sophora_10

Reduces inflammation, relieves itchiness and reinforces the skin barrier thanks to the power of quercetin.

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Thistle_10

Anti-inflamatory and repairing action, suitable for sensitive skin and rosacea.

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CBD_10 NAT

100% natural - for stronger, healthier and more balanced skin and hair.

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Ferulic_15

Effective photoprotection, calming effect and antiaging action in a single formula.

About Us

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At Optidel Biosystems, we develop biotechnological solutions for cosmetics, combining science, sustainability, and innovation in effective ingredients.

Contact

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We offer customized solutions for cosmetic brands: from ingredient design to validation and market readiness.