Sophora_10
Repairing and protective bioflavonoid
Quercetin can help treat skin conditions such as eczema and dermatitis due to its unique combination of anti-inflammatory, antioxidant, and immunomodulatory properties.
The quercetin used at Optidel Biosystems is extracted and purified from the flowers of Sophora japonica.
Quercetin (C₁₅H₁₀O₇) is a flavonoid, a type of plant pigment found in many fruits, vegetables and in flowers of plants such as Sophora japonica.
It acts as a powerful soothing and reparative bioactive, helping to restore balance in skin affected by eczema or rosacea. It visibly reduces redness and irritation through mast cell stabilization and by supporting cellular regeneration.
Sophora_10 strengthens and protects the skin barrier, restoring its natural equilibrium. Its innovative formulation calms, regenerates, and improves the skin’s immune response, leaving it more resilient, healthier, and visibly more radiant.
- check_circleThe Optidel technology makes it possible to concentrate a high amount of active ingredient while keeping it stable and bioavailable, thereby enhancing its efficacy.
- check_circleThanks to its structure, it is the easiest way to incorporate Sophora japonica quercetin into a wide range of cosmetic formulations.
- check_circleIt is a multifunctional ingredient, combining anti-inflammatory, antioxidant, and immunomodulating properties.
- check_circleAn excellent ally for treating and/or supporting various skin conditions.
How does it work?
Quercetin acts as a powerful antioxidant and anti-inflammatory agent.
Anti-inflammatory power
It effectively neutralizes free radicals (ROS), preventing oxidative damage and preserving the skin’s integrity and youthful appearance.
Repairing and protective antioxidant power
It modulates the inflammatory response by inhibiting pro-inflammatory mediators and key enzymes, promoting a calmer and more balanced skin state.
Intelligent immunomodulatory power
It reduces histamine release from mast cells, helping to minimize irritation, redness, and sensitivity, making it ideal for reactive or sensitive skin.
The Skin: A Living and Sensitive System in Constant Defense
The skin functions as a living and sensitive barrier, defending the body from external aggressors such as microbes, radiation, allergens, and chemical agents.. Made up of specialized cells and an interconnected immune network, its function can be affected by factors like stress, pollution, or excessive sun exposure, which may trigger inflammation and conditions such as dermatitis or rosacea
Cellular consequences
keyboard_arrow_downAlteration of the lipid barrier
Activation of the immune system
Damage to collagen and elastin fibers
Keratinocyte disfunction
Visible consequences
keyboard_arrow_downDry and dehydrated skin
Redness and skin inflammation
Hyperpigmentation
Loss of radiance
In-vitro Efficacy
Antioxidant activity: Advanced protection against environmental stress.
Over 110% ROS reduction
+20% more effective than vitamin C
With its potent activity, it helps maintain the skin looking younger and healthier.
- ROS reduction greater than 110%. Applications of Sophora-10 at 0.05% and 0.01% eliminate oxidative damage and restore antioxidant levels below baseline values.
- Superior antioxidant Sophora-10 not only reduces ROS to lower levels than healthy cells, but also surpasses the effectiveness of vitamin C by 20%.
See graph
keyboard_arrow_downROS production (%) in HaCaT keratinocyte cell line obtained from the antioxidant assay after 4 hours of exposure to tBPH with the test ingredient at the indicated concentrations. The positive control (tBPH insult) represents cells treated only with the oxidative agent tBPH. Bars represent the mean of six technical replicates from one independent experiment. Error bars indicate standard deviation. Statistical significance * p < 0.005.
Anti-inflammatory Activity
Demonstrated Anti-Inflammatory Action:
Concentration 0,01%
−45% IL-8 reduction
Concentration 0,05%
−56% IL-8 reduction
Sophora_10 effectively reduces the production of IL-8, a key marker in the inflammatory process, validating its use as a soothing and anti-inflammatory active ingredient in advanced cosmetic formulations.
See graph
keyboard_arrow_downIn vitro assay performed on differentiated human monocytic cells (THP-1), stimulated with LPS to induce inflammation. The compound was applied at different concentrations for 24 hours and its effect was evaluated by measuring IL-8 levels using ELISA. The reduction in this pro-inflammatory cytokine confirmed its anti-inflammatory activity.
Application
Sophora_10 is a unique and distinctive ingredient for creams, serums, toners, and soothing products, specially formulated to relieve sensitive skin, as well as skin affected by atopic dermatitis or rosacea.
Recommended dosage: 0,5% - 2%
Formulation Advice
Add in bulk during the final stage of the production process, ensuring the temperature does not exceed 40°C. Add to the mixture and maintain under stirring until fully homogeneous.
Active content (% w/w)
Quercetin at ≥ 8.5%
INCI name
INCI name: Dimethyl Isosorbide, Propylene Glycol, Sophora Japonica Flower Extract. CAS: 57-55-6, 5306-85-4, 90131-19-4
Documentation
If you want to know all the details about Optidel SOPHORA_10, you can download the documentation here. You'll find information about its features, how to use it, and the best recommendations for getting the most out of it.
Other Ingredients in Our Portfolio
Optidel Biosystems develops advanced biotechnological solutions for the cosmetics' industry.
Contact us
Bizkaia Science and Technology Park,
Building 202, 48170 Zamudio (Bizkaia)
info@optidelbiosystems.com
673 767 424 | 946 002 323
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