Luteolina_10
Depigmenting and antioxidant shield
Reveals radiant and even skin, reduces dark spots and protects against environmental stress.
Luteolin (C15H10O6) is a plant flavonoid from the flavone family recognized for its potent biological activity in the regulation of cellular stress. Naturally present in various botanical species such as Sophora japonica, it stands out for its ability to interact with key molecular pathways involved in inflammation, oxidative stress and irregular pigmentation.
In dermatology and cosmetics, luteolin combats oxidative stress, chronic inflammation and the appearance of dark spots. It limits cellular damage, protects the extracellular matrix and regulates melanin production for a more even skin tone.
Thus, it combines antioxidant, soothing and depigmenting action, making it an ideal plant-based active for formulas seeking luminosity, tone unification and protection against the exposome.
- check_circleOptidel technology allows a high concentration of active ingredient to be achieved, keeping it stable and bioavailable, enhancing its efficacy.
- check_circleThanks to its structure, it is the easiest way to add Sophora japonica luteolin to a wide range of cosmetic formulations.
- check_circleA biologically precise ingredient that acts on the two main drivers of skin aging: oxidative stress and chronic inflammation.
- check_circleIntelligent botanical defense against the oxidative stress and chronic inflammation responsible for skin aging.
How does it work?
Mechanisms of action.
Tyrosinase inhibition
Luteolin binds to tyrosinase, blocking its function. Reduces melanin accumulation in melanocytes. Prevents the formation of dark spots and localized pigmentation.
MITF regulation
MITF controls the genes that produce melanin in melanocytes. Luteolin modulates MITF expression, regulating melanogenesis at the genetic level and promoting a more even skin tone.
Antioxidant and anti-inflammatory activity
Neutralizes free radicals and reactive oxygen species (ROS). Reduces inflammatory mediators that stimulate post-inflammatory pigmentation. This protects the skin from dullness, inflammation and environmental stress, keeping it clearer, calmer and more radiant.
The origin of modern skin stress and skin dark spots
The skin is constantly exposed to environmental aggressions that generate oxidative stress and chronic inflammation, leading to irregular pigmentation. The exposome and other factors generate irregular pigmentation:
- UV radiation and visible light: Sun spots
- Inflammation and skin damage: Post-inflammatory dark spots
- Hormonal changes: Melasma
- Environmental exposure: Oxidative stress
These factors stimulate melanocytes and alter pigmentation.
In-vitro efficacy
Antioxidant effect: ROS activity test
Shows up to 163% improvement compared to healthy cells
Luteolina_10 significantly reduces ROS production under induced oxidative stress conditions, demonstrating potent cellular antioxidant activity.
•Luteolina_10 shows an improvement of up to 163% compared to healthy cells, positioning this ingredient as a potent anti-oxidative stress active for high-performance formulas.
•At concentrations of 0.04–0.07%, Luteolina_10 reduces ROS levels by ≈ 40% compared to healthy cells, meaning it improved the basal state of the cell.
These results position Luteolina_10 as a highly effective active in cellular protection against oxidative stress, helping to limit processes associated with chronic inflammation and premature aging induced by the exposome.
View chart
keyboard_arrow_downROS production (percentage) in the HaCaT keratinocyte cell line obtained in the antioxidant assay after 4 hours of exposure to tBPH with the test ingredient at the indicated percentages. The positive control, tBPH insult, represents cells with the oxidizing agent tBPH alone. Bars represent the mean of six technical replicates from an independent assay.
Photorepairing activity
Increases cell viability by 35-40%
Luteolina_10 promotes the recovery of cell viability after UV radiation-induced damage, significantly increasing cell survival compared to the damaged control.
Key result:
•The ingredient demonstrates photorepairing activity even at very low concentrations (0.01–0.04%), showing high biological efficiency.
•Luteolina_10 increases cell viability, restoring approximately 35–40% of the cell viability lost after UV damage.
These results support the use of Luteolina_10 as an active capable of supporting cellular repair mechanisms against photostress and contributing to the prevention of skin photoaging.
View chart
keyboard_arrow_downIn vitro assay performed on human keratinocytes (HaCaT) to evaluate repair capacity against solar damage. Cells were irradiated with simulated sunlight and treated with different concentrations of the compound for 24 h. Cell viability was measured using the MTT assay.
Application
Luteolina_10 is a versatile, high-efficacy ingredient for anti-aging creams and serums, soothing and anti-redness treatments for sensitive skin, products for oily and reactive skin care, and mild depigmenting or illuminating products.
Recommended dose: 0.5% - 2%
Formulation tips
Add to bulk during the final phase of the production process, ensuring the temperature does not exceed 40°C. Add to the mixture and keep under agitation until homogeneous.
Active % (w/w)
Total Luteolin: ≥ 9%
INCI name
INCI name: Propylene Glycol, Dimethyl
Isosorbide, Poloxamer 407, Luteolin.
Documentation
If you want to know all the details about Optidel Luteolina_10, here you can download the documentation. You will find information about its properties, how to use it and the best recommendations to get the most out of it.
Optidel Biosystems develops advanced biotechnological solutions for the cosmetics' industry.
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info@optidelbiosystems.com
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