Mangostina_10
Multitarget dermo-cosmetic active
Advanced protection against inflammatory skin aging.
The mangostin used in Optidel Biosystems is extracted and purified from the skin of the mangosteen fruit.
Mangostin (C24H26O6) is the main xanthonoid present in the pericarp of the Garcinia mangostana fruit (mangosteen). It is a lipophilic polyphenol of high natural purity that can be found in the form of α-mangostin, the most active isomer.
Mangostin stands out in dermatology and cosmetics for its multitarget capacity: antioxidant, anti-inflammatory, protective against photoaging, and defender of the extracellular matrix. Its action contributes to calmer, protected, firmer and more resilient skin against environmental aggressions and premature aging.
- check_circleOptidel technology allows a high concentration of active ingredient to be achieved, keeping it stable and bioavailable, enhancing its efficacy.
- check_circleThanks to its structure, it is the easiest way to add Garcinia mangostana mangostin to a wide range of cosmetic formulations.
- check_circleIngredient with triple biological action: antioxidant, photoprotective and anti-inflammatory for comprehensive cellular protection.
- check_circleExcellent botanical shield against photostress, inflammation and premature skin aging.
How does it work?
Mangostina_10 acts as a multifunctional active against the skin exposome, helping to protect, repair and soothe the skin to keep it more resilient, healthy and radiant.
Potent antioxidant defense
Mangostina_10 protects cells against oxidative damage, helping to neutralize free radicals and restore cell viability.
Protection and repair against photostress
Provides photoprotective and photorepairing activity, promoting cellular recovery after UV damage and helping to prevent photoaging.
Soothing anti-inflammatory action
Modulates the skin's inflammatory response, helping to reduce irritation and maintain calmer, more balanced skin.
Prevention of premature aging
By combating oxidative stress and UV damage, it helps preserve cellular integrity and delay visible signs of aging.
Comprehensive protection against environmental aggressions
Thanks to its triple antioxidant, photoprotective and anti-inflammatory action, MANGOSTINA_10 strengthens the skin's natural defenses against solar radiation, pollution and environmental stress.
Inflammaging: the silent accelerator of skin aging
Continuous exposure to UV radiation, pollution and environmental stress triggers chronic low-grade inflammation, or inflammaging. This process disrupts cellular balance and accelerates the structural and functional deterioration of the skin.
- Solar radiation. UVA/UVB/HEV/IR
- Environmental Pollution.
- Sleep disorders.
- Poor habits.
- Stress.
Mechanisms of action in sensitive skin
Continuous exposure to external aggressions induces persistent low-grade inflammation or Inflammaging, which accelerates skin aging.
Cellular consequences
keyboard_arrow_downOxidative stress
Excess ROS damages cell membranes, proteins and DNA, compromising the function of keratinocytes and fibroblasts.
The skin loses its capacity for defense, repair and resilience against external aggressions.
Persistent inflammation
Activation of NF-κB induces the release of pro-inflammatory mediators (TNF-α, IL-6, IL-1β), maintaining a chronic inflammatory state.
The inflammaging process is accelerated.
Extracellular matrix degradation
Increased MMPs promote the degradation of collagen and elastin.
Firmness, elasticity and the skin's regenerative capacity are reduced.
Visible consequences
keyboard_arrow_downInflammation and redness
More reactive skin
Loss of firmness
Premature aging
In-vitro efficacy
Potent cellular antioxidant protection
Restores up to ~75% of cell viability after oxidative damage.
Mangostina_10 demonstrates a marked capacity to protect skin cells against oxidative stress.
Key result:
•Restores up to ~75% of cell viability after oxidative damage.
•Notably decreases intracellular ROS production.
Biological impact:
•Prevents cellular oxidative damage.
•Improves cell survival under stress.
•Reinforces the skin's natural antioxidant defenses.
Mangostina_10 acts as a high-efficacy antioxidant shield, helping to maintain cellular vitality and youthfulness against oxidative aging.
View chart
keyboard_arrow_downROS production (%) in HaCaT keratinocytes after induction of oxidative stress with tBHP and treatment with Mangostina_10.
Photorepairing activity: Cellular recovery after UV damage
Increases cell viability by 42%
Mangostin demonstrates clear photorepairing activity, promoting the recovery of keratinocytes after exposure to UV radiation.
Key result:
•Mangostina_10 increases cell viability by 42% after UV damage, restoring approximately 25% of the lost cellular balance.
•Promotes cellular recovery even at very low concentrations (<0.005%).
Biological impact:
•Promotes cellular repair after UV stress
•Improves viability of damaged keratinocytes
•Contributes to the recovery of photostressed skin.
Mangostina_10 boosts natural cellular photorepair mechanisms, helping to protect the skin against UV radiation-induced photoaging.
View chart
keyboard_arrow_downIn vitro assay performed on human keratinocytes (HaCaT) to evaluate repair capacity against solar damage. Cells were irradiated with simulated sunlight and treated with different concentrations of the compound for 24 h. Cell viability was measured using the MTT assay.
Ex-vivo results
Optidel technology improves bioavailability and topical efficacy
Comparative ex vivo study evaluating the impact of the solubilization strategy on the topical efficacy of mangostin.
Compared to a conventional lipophilic vehicle (castor oil), in which mangostin shows greater affinity and apparent solubility, Optidel technology demonstrates greater functional bioavailability, translated into better preservation of collagen and elastin and recovery from photoaging damage.
View chart
keyboard_arrow_downEx vivo evaluation on human skin explants to determine collagen and elastin levels after treatment with mangostin. Data are expressed relative to healthy and photoaged controls; statistical significance *p < 0.05.
Application
O/W creams and lotions, sun care products, post-procedure or post-sun exposure formulas, soothing treatments for sensitive or irritated skin, products for acne-prone skin or rosacea and anti-aging products.
Recommended dose: 0.5% - 2%
Formulation tips
Add to bulk during the final phase of the production process, ensuring the temperature does not exceed 40°C.
Add to the mixture and keep under agitation until homogeneous.
Active % (w/w)
Total α-Mangostin: ≥ 5.5%
INCI name
INCI name: Propylene Glycol, Dimethyl
Isosorbide, Garcinia Mangostana (Mangosteen)
Peel Extract.
CAS: 57-55-6; 5306-85-4; 90045-25-3
Documentation
If you want to know all the details about Optidel Mangostina_10, here you can download the documentation. You will find information about its properties, how to use it and the best recommendations to get the most out of it.
Other Ingredients in Our Portfolio
Optidel Biosystems develops advanced biotechnological solutions for the cosmetics' industry.
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Bizkaia Science and Technology Park,
Building 202, 48170 Zamudio (Bizkaia)
info@optidelbiosystems.com
946 002 323
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